The patients were randomized to receive cryoballoon catheter ablation or standard-of-care medications. The STOP AF FIRST trial studied 203 patients with paroxysmal atrial fibrillation, not previously treated with medications, over the course of a year at 24 sites across the U.S. However, improvements in the safety and efficacy of catheter ablation have led to increased interest ablation as a first line of therapy. Paroxysmal atrial fibrillation is typically first treated with anti-arrthymic drugs. Patients with atrial fibrillation are five- to seven-times more likely to have a stroke than the general population. Atrial fibrillation can lead to serious issues such as blood clots, a decrease in the heart’s ability to pump blood and strokes. About 40 percent of patients with this condition have intermittent episodes of atrial fibrillation, called paroxysmal atrial fibrillation, which could eventually progress into persistent atrial fibrillation. The Centers for Disease Control and Prevention estimates it affects between 2.7 million and 6.1 million people in the United States. The study was presented today as a late-breaking clinical trial at the European Society of Cardiology meeting.Ītrial fibrillation is the most common type of heart rhythm disorder. Cleveland Clinic researchers have found that using a certain ablation procedure as the first treatment for intermittent atrial fibrillation may be more effective than standard-of-care management using medications.
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